Companion web site to
Eric Nikkelen, MSEE 1, Willem L. van Meurs, PhD 1,2,3,
and Maria A.K. Öhrn, MD 1:
Hydraulic analog for simultaneous representation of
pharmacokinetics and pharmacodynamics: Application to vecuronium
Journal of Clinical Monitoring and Computing, J Clin Monit Comput. 1998 Jul;14(5):329-37.
1Department of Anesthesiology, University of Florida
College of Medicine; 2Department of Electrical and
Computer Engineering, University of Florida College of Engineering;
3University of Florida Brain Institute.
You will need java on your machine to see the graphic below. If you see a blank, please go to www.java.com and click on the "get it now" button.
Copyright © 1998, University of Florida
Click on one of the dosing buttons to inject drug. EDxx: Effective
dose of vecuronium, resulting in xx % single twitch force depression.
IR50: infusion rate of vecuronium, resulting in 50% twitch force
depression. The simulation can be accelerated by clicking on the
buttons at the bottom of the hydraulic analog.
Fluid delivered into the central reservoir is equivalent to drug
infusion. The heights of the fluid columns in the central and
peripheral reservoirs are equivalent to the drug concentrations
in the corresponding pharmacologic compartments. The height of
the fluid column in the "effect reservoir" is equivalent
to the apparent effect site concentration in a simultaneous pharmacokinetic-pharmacodynamic
model. The non-linear scale on the effect reservoir represents
the relationship between the effect site concentration and the
clinical effect. 5, 50, and 95 % twitch force depression are indicated.